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Medical management of pituitary-dependent hyperadrenocorticism: mitotane versus trilostane.

Abstract
Pituitary-dependent hyperadrenocorticism is a common endocrine disorder in dogs in the United States. Once a diagnosis is established, a decision must be made whether or not to pursue treatment, and if so, which medication to use. Historically, mitotane (Lysodren, o,p'-DDD, Bristol-Myers Squibb, New York) has been the most commonly used treatment for medical management. Its use is complicated and comes with many potential side effects, making many practitioners wary of its use. Recently, trilostane has been proven to be an effective treatment of pituitary-dependent hyperadrenocorticism and is approved for use in other countries. Treatment with trilostane is somewhat simpler and the incidence of side effects seems to be less when compared with mitotane therapy. Either treatment can be a safe and effective method of treatment for pituitary-dependent hyperadrenocorticism when the practitioner and client are well educated regarding their use and an appropriate monitoring protocol is used.
AuthorsNyssa J Reine
JournalClinical techniques in small animal practice (Clin Tech Small Anim Pract) Vol. 22 Issue 1 Pg. 18-25 (Feb 2007) ISSN: 1096-2867 [Print] United States
PMID17542193 (Publication Type: Journal Article, Review)
Chemical References
  • Antineoplastic Agents, Hormonal
  • Dihydrotestosterone
  • Mitotane
  • trilostane
Topics
  • Adrenocortical Hyperfunction (drug therapy, veterinary)
  • Animals
  • Antineoplastic Agents, Hormonal (adverse effects, therapeutic use)
  • Dihydrotestosterone (adverse effects, analogs & derivatives, therapeutic use)
  • Dog Diseases (drug therapy)
  • Dogs
  • Mitotane (adverse effects, therapeutic use)
  • Safety
  • Treatment Outcome

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