Abstract | OBJECTIVE: PATIENTS AND METHODS: Patients were sequentially enrolled after obtaining informed consent. Twenty-three adult patients with SIRS were classified into the following groups; SIRS alone (5 patients), Group A of ALI/ARDS with SIRS (9 patients) that did not require mechanical ventilation, and Group B of ALI/ARDS with SIRS (9 patients) that required mechanical ventilation. Blood samples were obtained after the diagnosis of SIRS, and the sequential sampling was performed. RESULTS: The plasma neutrophil elastase level was significantly elevated in all patient groups as compared with healthy controls (43.7+/-5.4 ng/ml). The elastase levels in SIRS alone, Group A of ALI/ARDS, and Group B of ALI/ARDS were 126.9+/-11.0 ng/ml, 316.2+/-68.9 ng/ml, and 458.4+/-132.8 ng/ml, respectively. The elastase level in ALI/ARDS with SIRS was significantly greater than that in SIRS alone. The maximal level in 13 of 18 patients with ALI/ARDS with SIRS was more than 220 ng/ml. The level in all patients with SIRS alone was consistently less than 220 ng/ml over the study period. The serum levels of inflammatory cytokines were elevated in these patients, but no statistical significance was detected among the groups. CONCLUSION:
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Authors | Tadatomo Kodama, Hidekazu Yukioka, Takayuki Kato, Noboru Kato, Fumihiko Hato, Seiichi Kitagawa |
Journal | Internal medicine (Tokyo, Japan)
(Intern Med)
Vol. 46
Issue 11
Pg. 699-704
( 2007)
ISSN: 1349-7235 [Electronic] Japan |
PMID | 17541219
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Serine Proteinase Inhibitors
- Sulfonamides
- sivelestat
- Leukocyte Elastase
- Glycine
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Female
- Glycine
(analogs & derivatives, therapeutic use)
- Humans
- Leukocyte Elastase
(blood)
- Male
- Middle Aged
- Predictive Value of Tests
- Respiration, Artificial
- Respiratory Distress Syndrome
(blood, diagnosis, etiology)
- Serine Proteinase Inhibitors
(therapeutic use)
- Sulfonamides
(therapeutic use)
- Systemic Inflammatory Response Syndrome
(complications, therapy)
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