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Cognition-enhancing and neuroprotective effects of hederacolchiside-E from Pulsatilla koreana.

Abstract
The root extract of Pulsatilla koreana (Ranunculaceae) has been found to have prominent abilities to reverse scopolamine-induced cognitive impairment in rats, and to increase the viability of human neuroblastoma SK-N-SH cells incubated with amyloid-beta peptide (1 - 42) [A beta (1 - 42)]. In vivo and in vitro activity-guided fractionation studies using solvent-partitioning and subsequent chromatographic separations led to the isolation of hederacolchiside-E, an oleanolic glycoside, as an active ingredient. Administration of hederacolchiside-E (30 and 60 mg/kg body weight, P. O.) increased the step-through latency time in the passive avoidance test as efficiently as tacrine (30 mg/kg, P. O.). The neuroprotective effect of hederacolchiside-E on SK-N-SH cells against the toxicity of A beta (1 - 42) was comparable to that of catechin. These data suggest that hederacolchiside-E might be a good therapeutic candidate for the treatment of Alzheimer's disease.
AuthorsChang-Kyun Han, Won Rack Choi, Ki-Bong Oh
JournalPlanta medica (Planta Med) Vol. 73 Issue 7 Pg. 665-9 (Jun 2007) ISSN: 0032-0943 [Print] Germany
PMID17538873 (Publication Type: Journal Article)
Chemical References
  • Amyloid beta-Peptides
  • Neuroprotective Agents
  • Plant Extracts
  • Saponins
  • hederacolchiside E
Topics
  • Administration, Oral
  • Alzheimer Disease (prevention & control)
  • Amyloid beta-Peptides (toxicity)
  • Animals
  • Avoidance Learning (drug effects)
  • Cell Line, Tumor (drug effects)
  • Cognition (drug effects)
  • Dose-Response Relationship, Drug
  • Humans
  • Neuroprotective Agents (administration & dosage, pharmacology, therapeutic use)
  • Phytotherapy
  • Plant Extracts (administration & dosage, pharmacology, therapeutic use)
  • Plant Roots
  • Pulsatilla
  • Rats
  • Saponins (administration & dosage, pharmacology, therapeutic use)

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