New approach to noninvasive coronary angiography by multidetector computed tomography: initial experience using gadolinium.

Abstract

OBJECTIVE:

To investigate the gadolinium performance for 16-detector-row coronary computed tomography (CT) angiography.

METHODS:

Ethics committee approval and informed consent were obtained. Ten patients with coronary artery disease underwent digital coronary angiography and gadolinium-enhanced CT coronary angiography (Gd-CTCA) within the same week. For the Gd-CTCA, each patient received a dose of 0.3 mmol/kg of body weight of 0.5 mmol/mL gadoterate meglumine. Two readers interpreted the CT angiographies independently, and their results were matched with the digital angiography findings. The diagnostic accuracy of Gd-CTCA was calculated by the exact binomial method.

RESULTS:

Sensitivity, specificity, and positive and negative predictive values were for observer 1: 91.67%, 98.73%, 84.62%, and 99.36%, and for observer 2: 83.33%, 98.73%, 83.33%, and 98.73%, respectively.

CONCLUSION:

Preliminary results demonstrated that gadolinium chelates may be used as an alternative CT contrast media in coronary CT angiographies, without detriment to diagnosis results.

• Authors: Patricia Carrascosa, Pablo Garcia Merletti, Carlos Capuñay, Alejandro Goldsmit, Marcelo Bettinotti, Jorge Carrascosa
• Journal: Journal of computer assisted tomography (J Comput Assist Tomogr) 2007 May-Jun Vol. 31 Issue 3 Pg. 441-3 ISSN: 0363-8715 [Print] United States
• PMID: 17538293 (Publication Type: Journal Article)

Chemical References

• Contrast Media
• Organometallic Compounds
• Meglumine
• gadoterate meglumine

Topics

• Cardiovascular Diseases (diagnostic imaging)
• Contrast Media
• Coronary Angiography (methods)
• Humans
• Male
• Meglumine
• Middle Aged
• Organometallic Compounds
• Predictive Value of Tests
• Sensitivity and Specificity
• Tomography, X-Ray Computed