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Chitotriosidase as a marker of disease activity in sarcoidosis.

Abstract
Sarcoidosis is a chronic granulomatous inflammation. The clinical spectrum in childhood is heterogeneous. Angiotensin converting enzyme (ACE) activity is used as a marker for disease activity. Human chitotriosidase is produced in macrophages. In this study serum chitotriosidase levels were significantly higher in active sarcoidosis, than in inactive disease or healthy controls. Serum chitotriosidase concentrations may be a useful marker for monitoring disease activity in sarcoidosis.
AuthorsJürgen Brunner, Sabine Scholl-Bürgi, Lothar-Bernd Zimmerhackl
JournalRheumatology international (Rheumatol Int) Vol. 27 Issue 12 Pg. 1171-2 (Oct 2007) ISSN: 0172-8172 [Print] Germany
PMID17534622 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Biomarkers
  • Hexosaminidases
  • chitotriosidase
  • Peptidyl-Dipeptidase A
Topics
  • Adolescent
  • Biomarkers (blood)
  • Female
  • Hexosaminidases (blood)
  • Humans
  • Peptidyl-Dipeptidase A (blood)
  • Sarcoidosis (blood, diagnosis, enzymology)

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