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Effects of treatment with trihexyphenidyl on cognitive function in early Parkinson's disease.

Abstract
13 patients with PD of recent onset underwent a series of neuropsychological tests for frontal lobe associated functions (Sternberg paradigm, WCST, CVLT) before and during treatment with Artane. Test results at baseline were not significantly different from those of an age-matched control group (n = 13). Retesting after a mean of 2 weeks' treatment with trihexyphenidyl revealed only slight impairment in CVLT while performance on the other tests remained unchanged.
AuthorsL Schelosky, T Benke, W H Poewe
JournalJournal of neural transmission. Supplementum (J Neural Transm Suppl) Vol. 33 Pg. 125-32 ( 1991) ISSN: 0303-6995 [Print] Austria
PMID1753241 (Publication Type: Journal Article)
Chemical References
  • Trihexyphenidyl
Topics
  • Adult
  • Aged
  • Cognition Disorders (drug therapy)
  • Female
  • Humans
  • Intelligence Tests
  • Male
  • Memory Disorders (diagnosis)
  • Middle Aged
  • Neuropsychological Tests
  • Parkinson Disease (drug therapy)
  • Reference Values
  • Time Factors
  • Trihexyphenidyl (therapeutic use)

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