Abstract |
The purpose of this study was to define binodenoson dosing regimens that produce coronary hyperemia comparable to those of adenosine and that are tolerated well by patients. An open-label, randomized, parallel-group, multicenter study enrolled adult patients who had completed diagnostic cardiac catheterization. Coronary blood flow velocity (CBFV) was measured with a Doppler flow wire, and CBFV reserve was determined before binodenoson administration. Patients (n = 133) received a 3-minute infusion of 0.3, 0.5, or 1 microg/kg/min or a bolus intravenous injection of 1.5 or 3 microg/kg. Coronary hyperemic responses were evident within seconds of administering binodenoson, and the magnitudes and durations of coronary hyperemic responses were dose related. The 1.5- and 3-microg/kg doses, by infusion or bolus, produced maximal coronary hyperemia equivalent to CBFV reserve. All doses transiently decrease blood pressure and increased heart rate and rate-pressure product. In conclusion, the 1.5-microg/kg binodenoson bolus dose produced nearly maximal coronary hyperemia by 4.5 +/- 3.7 minutes that was sustained for 7.4 +/- 6.86 minutes, was accompanied by modest changes in blood pressure, heart rate, and rate-pressure product, and produced no adverse changes on electrocardiogram, including no second- or third-degree atrioventricular block.
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Authors | John McB Hodgson, Nabil Dib, Morton J Kern, Richard G Bach, Richard J Barrett |
Journal | The American journal of cardiology
(Am J Cardiol)
Vol. 99
Issue 11
Pg. 1507-12
(Jun 01 2007)
ISSN: 0002-9149 [Print] United States |
PMID | 17531571
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Adenosine A2 Receptor Agonists
- Adenosine
- binodenoson
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Topics |
- Adenosine
(administration & dosage, analogs & derivatives, pharmacology)
- Adenosine A2 Receptor Agonists
- Adult
- Aged
- Aged, 80 and over
- Analysis of Variance
- Blood Flow Velocity
(drug effects)
- Blood Pressure
(drug effects)
- Coronary Circulation
(drug effects)
- Coronary Vessels
(diagnostic imaging, drug effects, physiopathology)
- Dose-Response Relationship, Drug
- Female
- Heart Rate
(drug effects)
- Humans
- Hyperemia
(chemically induced, physiopathology)
- Infusions, Intravenous
- Injections, Intravenous
- Male
- Middle Aged
- Time Factors
- Treatment Outcome
- Ultrasonography, Doppler
- Vascular Resistance
(drug effects)
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