Abstract | BACKGROUND: METHODS: Twenty-four CADASIL subjects were treated with atorvastatin for 8 weeks. Treatment was started with 40 mg, followed by a dosage increase to 80 mg after 4 weeks. Transcranial Doppler sonography measuring mean flow velocity (MFV) in the middle cerebral artery was performed at baseline and the end of the treatment period. Vasoreactivity was assessed by hypercapnia and intravenous application of l-Arginine, which is the substrate for eNOS. RESULTS: There was no significant treatment effect on MFV (p=0.5) or cerebral vasoreactivity as assessed by hypercapnia (p=0.5) and intravenous l-Arginine (p=0.4) in the overall cohort. However, an inverse correlation was found between vasoreactivity at baseline and changes of both CO2 and l-Arginine-induced vasomotor response (both p<0.05). CONCLUSIONS: Short term treatment with atorvastatin resulted in no significant improvement of hemodynamic parameters in the overall cohort of CADASIL subjects.
|
Authors | Nils Peters, Tobias Freilinger, Christian Opherk, Thomas Pfefferkorn, Martin Dichgans |
Journal | Journal of the neurological sciences
(J Neurol Sci)
Vol. 260
Issue 1-2
Pg. 100-5
(Sep 15 2007)
ISSN: 0022-510X [Print] Netherlands |
PMID | 17531269
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Heptanoic Acids
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Pyrroles
- Carbon Dioxide
- Nitric Oxide
- Arginine
- Atorvastatin
|
Topics |
- Adult
- Arginine
(pharmacology)
- Atorvastatin
- CADASIL
(diagnostic imaging, drug therapy, physiopathology)
- Carbon Dioxide
(blood)
- Cerebral Arteries
(diagnostic imaging, drug effects, physiopathology)
- Cerebrovascular Circulation
(drug effects, physiology)
- Cohort Studies
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Female
- Heptanoic Acids
(therapeutic use)
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Hypercapnia
(chemically induced, physiopathology)
- Hypoxia-Ischemia, Brain
(drug therapy, etiology, physiopathology)
- Male
- Middle Aged
- Middle Cerebral Artery
(diagnostic imaging, drug effects, physiopathology)
- Nitric Oxide
(metabolism)
- Pyrroles
(therapeutic use)
- Treatment Outcome
- Ultrasonography, Doppler, Transcranial
- Vasodilation
(drug effects, physiology)
|