Abstract | BACKGROUND: METHODS: RESULTS: Intragastric administration of MNNG induced well-differentiated squamous cell carcinomas that showed diminished lipid and protein oxidation and an increase in antioxidant status. This was associated with increased cell proliferation, angiogenesis, and invasive potential coupled with apoptosis evasion as revealed by upregulation of PCNA, GST-pi, Bcl-2, cytokeratins, and VEGF and downregulation of Bax, cytochrome C, and caspase 3 protein expression. Dietary administration of Polyphenon-B effectively suppressed MNNG-induced gastric carcinogenesis, as evidenced by modulation of oxidant- antioxidant status, inhibition of cell proliferation and infiltration, and angiogenesis associated with apoptosis induction. CONCLUSIONS: The present study provides evidence that Polyphenon-B exerts multifunctional inhibitory effects on MNNG-induced gastric carcinogenesis and suggests that it can be developed as a potential chemopreventive agent.
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Authors | Ramalingam Senthil Murugan, Kurapathy Venkata Poorna Chandra Mohan, Koji Uchida, Yukihiko Hara, Duvuru Prathiba, Siddavaram Nagini |
Journal | Journal of gastroenterology
(J Gastroenterol)
Vol. 42
Issue 5
Pg. 352-61
(May 2007)
ISSN: 0944-1174 [Print] Japan |
PMID | 17530359
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aldehydes
- Antioxidants
- Oxidants
- Phenols
- Proliferating Cell Nuclear Antigen
- Thiobarbituric Acid Reactive Substances
- polyphenon B
- Methylnitronitrosoguanidine
- 4-hydroxy-2-nonenal
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Topics |
- Aldehydes
(metabolism)
- Animals
- Antioxidants
(metabolism)
- Apoptosis
- Cell Proliferation
- Chemoprevention
- Disease Models, Animal
- Down-Regulation
(physiology)
- Immunohistochemistry
- Lipid Peroxidation
- Male
- Methylnitronitrosoguanidine
- Oxidants
(metabolism)
- Oxidation-Reduction
- Phenols
(pharmacology)
- Proliferating Cell Nuclear Antigen
(metabolism)
- Rats
- Rats, Wistar
- Stomach
(pathology)
- Thiobarbituric Acid Reactive Substances
- Up-Regulation
(physiology)
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