[Changes of the goldfish Mauthner neuron ultrastructure and function under the influence of 3,4-dihydro-2(1H)-pyrimidinethione].

Abstract

The effects of pyrimidine derivative 3,4-dihydro-2(1H)-pyrimidinethione, (DPT) used as a test-system for detection of tumor growth, on the goldfish Mauthner neurons (MN) ultrastructure and function, as manifested in behavioral changes, were studied. The results of investigations demonstrated that an application of DPT on MN had the effects similar to those of dopamine application, as established earlier, causing the enhancement of MN resistance to fatigue stimulation, accompanied by an increase of the dimensions of the actin containing desmosome-like afferent admembranous synaptic contacts, and formation of the cytoplasmic bundles of actin stress-fibers. Similarity of morpho-functional changes of MN, induced by DPT, an artificial chemical substance, which has no receptors on the neuronal membrane, and by natural neurotransmitter dopamine, allows us to suggest possible trophic stabilizing and polymerizing effects of both substances on cytoskeletal actin due to their direct penetration into postsynaptic neuron.

• Authors: L L Pavlik, E N Bezgina, V S Shubina, Iu V Shatalin, M M Potselueva, D A Moshkov
• Journal: Morfologiia (Saint Petersburg, Russia) (Morfologiia) Vol. 131 Issue 1 Pg. 31-6 ( 2007) ISSN: 1026-3543 [Print] Russia (Federation)
• PMID: 17526260 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 3,4-dihydro-2(1H)-pyrimidinethione
• Actins
• Pyrimidines
• Thiones

Topics

• Actins (ultrastructure)
• Animals
• Desmosomes (drug effects, ultrastructure)
• Electric Stimulation
• Goldfish (physiology)
• Motor Activity
• Neurons (drug effects, ultrastructure)
• Pyrimidines (pharmacology)
• Synapses (drug effects, ultrastructure)
• Synaptic Transmission
• Thiones (pharmacology)