Patterns of in vitro lymphoproliferative responses among HTLV-1-infected subjects: upregulation by HTLV-1 during HIV-1 co-infection.

Abstract

The present study evaluated the in vitro response to different mitogens and a candidin antigen (CMA) in Human T-cell lymphotropic virus type 1 (HTLV-1) and co-infected HIV-1/HTLV-1 patients, to identify if this co-infection may modify the spontaneous lymph proliferative response. Peripheral blood mononuclear cells from 72 healthy seronegative controls, 75 asymptomatic HTLV-1-infected carriers, 42 HAM/TSP cases, 33 solely HIV-1-infected subjects and 24 HIV-1/HTLV-1 patients were assayed in the presence and absence of mitogens (PHA, PWM and OKT3) and CMA. The HAM/TSP group had the highest proliferation rate at 3 and 6 days after culture. HAM/TSP cases showed decreased response to PHA, compared with asymptomatic HTLV-1 subjects, and most important, the co-infected HIV-1/HTLV-1 cases presented a similar response to HTLV-1-infected subjects after 3 days of culture. The singles HIV-1-infected group had decreased in vitro response. It appears that during co-infection, the HTLV-1 regulatory proteins overwhelm the action of HIV-1 regulatory proteins.

• Authors: I Olah, L M I Fukumori, P Montanheiro, M P Vergara, J Smid, A J S Duarte, A C Penalva de Oliveira, J Casseb
• Journal: Scandinavian journal of immunology (Scand J Immunol) Vol. 65 Issue 6 Pg. 577-80 (Jun 2007) ISSN: 0300-9475 [Print] England
• PMID: 17523951 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Mitogens

Topics

• CD4-Positive T-Lymphocytes (immunology, virology)
• CD8-Positive T-Lymphocytes (immunology, virology)
• Carrier State (blood, immunology)
• Cell Proliferation (drug effects)
• Cells, Cultured
• Comorbidity
• HIV Infections (epidemiology, immunology)
• HTLV-I Infections (blood, epidemiology, immunology)
• Humans
• Leukocytes, Mononuclear (immunology)
• Lymphocyte Count
• Mitogens (pharmacology)
• Myelitis (blood, epidemiology, immunology)
• Paraparesis, Tropical Spastic (blood, epidemiology, immunology, virology)