The authors studied the duration of intragastric
acid production at 20 mg of
pariet in patients with hypergastric
gastritis after determination of the individual type of parietal gastric cell reception. The study included 40 patients (12 women and 28 men aged 33.3 +/- 6.7 years). Predominant activity of
H2 receptors was detected in 32 patients, while M-cholinoreceptor activity prevailed in six patients; in two patients receptor type was not defined. Latent period (3.1 +/- 0.5 hours), pH(max) (5.4 +/- 0.7), pH24h (3.5 +/- 0.4), pH(stimulated24h) (3.0 +/- 0.7) did not depend on the predominant sensitivity of either receptor type and was significantly higher in patients taking
pariet than in patients receiving standard doses of
omeprazole (2.2 +/- 0.5 h, 4.0 +/- 0.3, 2.4 +/- 0.3, and 1.2 +/- 0.3, respectively) or
lansoprazole (2.2 +/- 0.6, 4.3 +/- 0.6, 2.6 +/- 0.3, and 1.3 +/- 0.3, respectively). The clinical effectiveness of
pariet was evaluated in 20 patients (15 men and 5 women aged 51.6 +/- 5.4) after gastric resection, needing antisecretory
therapy. Individual reception type was studied. The effects of
pirenzepine and
ranitidine (or
famotidine) given in standard doses at the beginning of the week were studied in patients with predominant H2-hystaminergic, M-
cholinergic, or unclear type. After that all patients received
pariet 20 mg a day. None of the patients displayed predominant H2 receptor activity. In 14 patients predominant M-cholinoreceptor activity was noted; in six patients receptor type remained unclear. All the patients were administered
ranitidine (or
famotidine) during one week with no clinical effect. Six patients with unclear reception type were given gastrozepine for one more week, with no effect either. After the beginning of
pariet 20 mg a day complaints disappeared in all patients within one or two days. The conclusion is that
pariet in a standard dose possesses higher antisecretory effect vs. other
proton pump inhibitors, unlike that of H2
histamine blockers, the latter not depending on the individual type of gastric parietal cell reception.