HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Circadian rhythm of the toxicokinetics and toxicodynamics of the plant protection substance dinitro-ortho-cresol in rabbits].

Abstract
Results from chronotoxicological investigations with the plant protection chemical DNOC has been described and judged. It has been studied hyperthermia caused by i.v. application of 7.5 mg/kg body weight on rabbits to 6 different times, starting at 4 a.m. with 4-hours-intervals as well as the dose-effect relation in each case with 3 doses to the time of application at 12 a.m., 6 p.m., 12 p.m. and 6 a.m. and the renal DNOC excretion after a dose of 10 mg/kg body weight. There was found a time dependent rhythm in all experiments. Acrophase of hyperthermia is placed in the middle of the phase of activity of the animals at 12 p.m., however it depends on the dose. The results are showing, that the position of acrophase by constant environmental factor is neither a substance specific nor an animal specific constant.
AuthorsS Krüger, M Herzog, H Kuhlmey, E Werner
JournalDTW. Deutsche tierarztliche Wochenschrift (Dtsch Tierarztl Wochenschr) Vol. 98 Issue 10 Pg. 376-81 (Oct 1991) ISSN: 0341-6593 [Print] Germany
Vernacular TitleCircadiane Rhythmik der Toxikokinetik und -dynamik des Pflanzenschutzmittels DNOC (Dinitro-ortho-kresol) beim Kaninchen.
PMID1752207 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Dinitrocresols
  • Herbicides
  • Insecticides
  • 4,6-dinitro-o-cresol
Topics
  • Animals
  • Circadian Rhythm
  • Dinitrocresols (pharmacokinetics, toxicity)
  • Dose-Response Relationship, Drug
  • Female
  • Herbicides (pharmacokinetics, toxicity)
  • Insecticides (pharmacokinetics, toxicity)
  • Rabbits

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: