Activities of Z-ajoene against tumour and viral spreading in vitro.

Abstract	Z-ajoene is a garlic-derived compound with known anti-tumour properties. This report argues in favour of pro-apoptotic and cell cycle blockage activities of Z-ajoene on various cell lines involving activation of the p53-family gene products, p53, p63 and p73, at indicated doses. According to its known anti-proteasome activity, Z-ajoene induced a downregulation of MHC-class I expression at the surface of treated cells but did not impair their recognition by CD8+ T cells. We further demonstrated a new activity of Z-ajoene against human cytomegalovirus spreading in vitro that was mediated by an increased number of apoptotic cells after infection. Altogether our data point at the ubiquitous efficiency of Z-ajoene as a new compound to fight against cancers of various origins including those that put up viruses.
Authors	Jerome Terrasson, Bo Xu, Min Li, Sophie Allart, Jean-Luc Davignon, Li-he Zhang, Kui Wang, Christian Davrinche
Journal	Fundamental & clinical pharmacology (Fundam Clin Pharmacol) Vol. 21 Issue 3 Pg. 281-9 (Jun 2007) ISSN: 0767-3981 [Print] England
PMID	17521297 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents DNA-Binding Proteins Disulfides HLA-A2 Antigen Nuclear Proteins RNA, Messenger Sulfoxides TP63 protein, human TP73 protein, human Trans-Activators Transcription Factors Tumor Protein p73 Tumor Suppressor Protein p53 Tumor Suppressor Proteins ajoene Proteasome Endopeptidase Complex
Topics	Antineoplastic Agents (pharmacology) Apoptosis (drug effects) CD8-Positive T-Lymphocytes (drug effects, immunology) Cell Line, Tumor Cytomegalovirus (drug effects, physiology) DNA-Binding Proteins (genetics, metabolism) Disulfides (pharmacology) Fibroblasts (drug effects, virology) Genes, MHC Class I (physiology) HLA-A2 Antigen (metabolism) Humans Nuclear Proteins (genetics, metabolism) Proteasome Endopeptidase Complex (metabolism) RNA, Messenger (metabolism) Sulfoxides Trans-Activators (genetics, metabolism) Transcription Factors Tumor Protein p73 Tumor Suppressor Protein p53 (genetics, metabolism) Tumor Suppressor Proteins (genetics, metabolism)

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