[The influence of 3-oxypyridine antioxidants on depression in patients with diabetes mellitus].

Abstract

The authors studied the influence of 3-oxypyridine derivates (emoxypine and mexidol) on the degree of depressive symptoms in patients with diabetes mellitus; the data were matched with the dynamics of blood lipoperoxidation. The study found that administration of emoxypine (150 mg every day) or mexidol (300 mg a day) during 14 days lowered the level of circulating lipoperoxidation products and diminished manifestations of depression, which was accompanied by improvement in cognitive functions and quality of life; the degree of the changes was similar. These clinical effects of 3-oxypyridine derivates were independent of the dynamics of glycemia and lipidemia.

• Authors: I A Volchegorskiĭ, N V Mester
• Journal: Klinicheskaia meditsina (Klin Med (Mosk)) Vol. 85 Issue 2 Pg. 40-5 ( 2007) ISSN: 0023-2149 [Print] Russia (Federation)
• PMID: 17520888 (Publication Type: Controlled Clinical Trial, Journal Article)

Chemical References

• 3-oxypyridine
• Antioxidants
• Picolines
• Pyridines
• emoxypine succinate
• 6-methyl-2-ethyl-3-hydroxypyridine

Topics

• Adult
• Antioxidants (therapeutic use)
• Depressive Disorder, Major (drug therapy, epidemiology)
• Diabetes Mellitus (epidemiology)
• Female
• Humans
• Male
• Middle Aged
• Picolines (therapeutic use)
• Prospective Studies
• Pyridines (therapeutic use)