HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Protective effect of Rumex patientia (English Spinach) roots on ferric nitrilotriacetate (Fe-NTA) induced hepatic oxidative stress and tumor promotion response.

Abstract
In this communication, we document the antioxidant potential of ethanolic extract of Rumex patientia L. (Polygonaceae) roots and its chemopreventive effects against Fe-NTA mediated hepatic oxidative stress, hepatotoxicity and tumor promotion response. The extract exhibited high polyphenolic content, potent reducing power and significantly scavenged free radicals (including several reactive oxygen species (ROS) and reactive nitrogen species (RNS)). The extract also significantly and dose dependently protected against oxidative damage to lipids and DNA. These results indicated R. patientia root extract to exert a potent antioxidant activity in vitro. The efficacy of extract was also evaluated in vivo and it was found to exert a potent protective affect in acute oxidative tissue injury animal model: ferric nitrilotriacetate (Fe-NTA) induced hepatotoxicity in mice. Administration of Fe-NTA (9 mg/kg body weight, i.p.) to mice led to a significant oxidative stress and allied damage in liver tissues and induced hyperproliferation. A significant depletion was observed in GSH content and enzymes implicated in its metabolism. Attenuation also occurred in activities of other hepatic antioxidant enzymes including SOD, CAT, and GPX. Fe-NTA also incited hyperproliferation response elevating ornithine decarboxylase activity and [(3)H]-thymidine incorporation into DNA. Histopathological investigations and liver function tests (LFT) indicated Fe-NTA to cause extensive hepatic damage. However, prophylactic treatment with R. patientia root extract at a dose regimen of 100-200mg/kg body weight for a week not only restored hepatic antioxidant armory close to normal, but also significantly precluded oxidative damage restoring normal hepatic architecture and levels of hepatic damage markers. The data obtained in the present study illustrates R. patientia roots to possess potent antioxidant and free radical scavenging activities and thwart oxidative damage and hyperproliferation in hepatic tissues.
AuthorsIrshad A Lone, Gurpreet Kaur, Mohammad Athar, M Sarwar Alam
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 45 Issue 10 Pg. 1821-9 (Oct 2007) ISSN: 0278-6915 [Print] England
PMID17517459 (Publication Type: Journal Article)
Chemical References
  • Carcinogens
  • Ferric Compounds
  • Phenols
  • Plant Extracts
  • Reducing Agents
  • DNA
  • Superoxide Dismutase
  • Ornithine Decarboxylase
  • Glutathione
  • Nitrilotriacetic Acid
  • ferric nitrilotriacetate
Topics
  • Animals
  • Carcinogens (antagonists & inhibitors, chemistry)
  • DNA (biosynthesis, genetics)
  • DNA Damage (drug effects)
  • Female
  • Ferric Compounds (antagonists & inhibitors, chemistry)
  • Glutathione (metabolism)
  • Lipid Peroxidation (drug effects)
  • Liver (drug effects, metabolism)
  • Liver Function Tests
  • Mice
  • Nitrilotriacetic Acid (analogs & derivatives, antagonists & inhibitors, chemistry)
  • Ornithine Decarboxylase (metabolism)
  • Oxidative Stress (drug effects)
  • Phenols (chemistry, pharmacology)
  • Plant Extracts (chemistry, pharmacology)
  • Plant Roots (chemistry)
  • Reducing Agents (chemistry)
  • Rumex (chemistry)
  • Superoxide Dismutase (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: