Modulation of the immune system by dying cells and the phosphatidylserine-ligand annexin A5.

Abstract

Apoptotic cell death and the efficient clearance of dying cells are essential mechanisms to control tissue homeostasis and to eliminate potential autoantigens. Numerous alterations on the surfaces of dying cells define a highly characteristic membrane signature and enable an unequivocal distinction from vital cells. This way, phagocytosis is initiated and signalling events induced which minimize inflammatory reactions. Therefore, the use of proteins interfering with the clearance process may open up new vistas to improve immunization strategies and may help to understand the mechanisms of autoimmune diseases.

• Authors: Udo S Gaipl, Luis E Munoz, Franz Rödel, Friederike Pausch, Benjamin Frey, Bent Brachvogel, Klaus von der Mark, Ernst Pöschl
• Journal: Autoimmunity (Autoimmunity) Vol. 40 Issue 4 Pg. 254-9 (Jun 2007) ISSN: 0891-6934 [Print] England
• PMID: 17516206 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Annexin A5
• Autoantigens
• Ligands
• Phosphatidylserines

Topics

• Animals
• Annexin A5 (immunology)
• Autoantigens (immunology)
• Autoimmune Diseases (immunology, prevention & control)
• Cell Death
• Cell Membrane (immunology)
• Humans
• Immunization
• Ligands
• Phagocytosis (immunology)
• Phosphatidylserines (immunology)
• Signal Transduction (immunology)