[Ketoprofen in the prevention of postoperative pain in abdominal surgery. A multicenter study].

Two-hundred-forty-eight patients undergoing abdominal surgery were admitted to a multicentric clinical trial. The patients were randomly assigned to a single i.v. dose of ketoprofen or acetylsalicylic acid, 15 minutes after the end of operation. Ketoprofen showed a better analgesic activity with a statistically significant difference at 2 and 4 hours after administration. Two patients treated with ketoprofen reported vomiting and skin rash respectively. The results of this study confirm the efficacy of ketoprofen for the prophylaxis of postoperative pain in abdominal surgery.
AuthorsG Avila, G Balbo, R Biasiato, F M Brighenti, R Conte, I Donini, E Landi, G Marzocca, U Mazzi, F Morino
JournalIl Giornale di chirurgia (G Chir) 1991 Aug-Sep Vol. 12 Issue 8-9 Pg. 456-8 ISSN: 0391-9005 [Print] ITALY
Vernacular TitleIl ketoprofene nella profilassi del dolore postoperatorio in chirurgia addominale. Studio multicentrico.
PMID1751342 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Analgesics
  • acetylsalicylic acid lysinate
  • Ketoprofen
  • Lysine
  • Aspirin
  • Abdomen (surgery)
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Analgesics (therapeutic use)
  • Aspirin (analogs & derivatives, therapeutic use)
  • Drug Tolerance
  • Female
  • Humans
  • Ketoprofen (therapeutic use)
  • Lysine (analogs & derivatives, therapeutic use)
  • Male
  • Middle Aged
  • Pain, Postoperative (prevention & control)

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