Abstract | BACKGROUND: AIM: To outline the key molecular changes in oesophageal adenocarcinoma and to summarize the chemopreventative and therapeutic strategies proposed. METHODS: A literature search was performed to identify appropriate research papers in the field. Search terms included: Barrett's (o)esophagus, intestinal metaplasia, (o)esophageal adenocarcinoma, molecular changes, genetic changes, pathogenesis, chemoprevention, therapeutic strategies and treatment. The search was restricted to English language articles. RESULTS: CONCLUSIONS: Advances in molecular methodology have led to a greater understanding of the oesophageal adenocarcinoma pathways, which provides opportunities for chemoprevention and therapeutic strategies with a mechanistic basis. More work is required to assess both the safety and efficacy of these new treatments.
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Authors | C J Peters, R C Fitzgerald |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 25
Issue 11
Pg. 1253-69
(Jun 01 2007)
ISSN: 0269-2813 [Print] England |
PMID | 17509094
(Publication Type: Journal Article, Review, Systematic Review)
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Chemical References |
- Angiogenesis Inhibitors
- Anti-Inflammatory Agents
- Antioxidants
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Topics |
- Adenocarcinoma
(etiology, prevention & control)
- Angiogenesis Inhibitors
(therapeutic use)
- Anti-Inflammatory Agents
(therapeutic use)
- Antioxidants
(therapeutic use)
- Cell Proliferation
- Chemoprevention
(methods)
- Disease Progression
- Duodenogastric Reflux
(prevention & control)
- Esophageal Neoplasms
(etiology, prevention & control)
- Genes, erbB
- Humans
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