Naproxen sodium in short-term prophylaxis of pure menstrual migraine: pathophysiological and clinical considerations.

Abstract

We investigated the biological and clinical effects of naproxen sodium (NxS) in the short-term prophylaxis of pure menstrual migraine (PMM) in 25 women suffering from migraine without aura, occurring exclusively from 2 days before to 5 days after menstruation onset. Daily oral NxS (550 mg) from 7 days before menstruation to 7 days after menstruation onset was given for 3 menstrual cycles, and 5 days before menstruation to 5 days after menstruation onset over the next 3 menstrual cycles. In the month before initiation of treatment and in the third month of treatment, 6-keto-PGF1(alpha), TXB(2) and PGE(2) were measured in plasma before menstruation (day -2) and on the second day (day +2) after bleeding onset. In the 20 women analysed, 6-keto-PGF1(alpha) was 17% lower (p<0.0001) and TXB(2) was 30% lower (p<0.0001) on day -2 during treatment than the same day pretreatment; TXB(2) was also lower (p<0.02) on day +2 during treatment than day +2 pretreatment. The 6-keto-PGF1(alpha)/TXB(2) ratio was higher (p<0.01) on day -2 treatment than day -2 pretreatment. PGE(2) levels were significantly lower (p<0.002) on day +2 than pre-treatment values on the same day. The number of attacks reduced from 1.7+/-0.11 pretreatment to 1.2+/-0.10 at the 3rd month (p<0.001), to 1.1+/-0.06 at the 6th month (p<0.0001). The duration reduced from 25.6+/-4.42 h pretreatment to 15.5+/-4.43 h in the 3rd month (p<0.02), to 13.35+/-4.26 h in the 6th month (p<0.001). The intensity reduced from 2.4+/-0.11 pretreatment, to 1.2+/-0.10 in the 3rd month of treatment (p<0.0001), and 1.1+/-0.07 in the 6th month (p<0.0001).

• Authors: G Allais, G Bussone, C De Lorenzo, I Castagnoli Gabellari, M Zonca, O Mana, P Borgogno, G Acuto, C Benedetto
• Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (Neurol Sci) Vol. 28 Suppl 2 Pg. S225-8 (May 2007) ISSN: 1590-1874 [Print] Italy
• PMID: 17508177 (Publication Type: Journal Article)

Chemical References

• Cyclooxygenase Inhibitors
• Thromboxane B2
• Naproxen
• 6-Ketoprostaglandin F1 alpha
• Dinoprostone

Topics

• 6-Ketoprostaglandin F1 alpha (blood)
• Administration, Oral
• Adult
• Cyclooxygenase Inhibitors (administration & dosage)
• Dinoprostone (blood)
• Down-Regulation (drug effects, physiology)
• Drug Administration Schedule
• Female
• Humans
• Menstruation Disturbances (complications, physiopathology)
• Middle Aged
• Migraine Disorders (etiology, physiopathology, prevention & control)
• Naproxen (administration & dosage)
• Predictive Value of Tests
• Thromboxane B2 (blood)
• Time Factors
• Treatment Outcome