Influence of bromopride in the prophylaxis of nausea associated with fluorescein angiography.

Abstract

PURPOSES:

To determine the efficacy of bromopride in the prophylaxis of nausea during fluorescein angiography, when compared with a placebo.

METHODS:

The study was a double-masked random clinical trial, between December of 2004 and April of 2005. Examinations were performed with 20% intravenous fluorescein sodium in a single dose of 2.5 ml. The patients were divided into two groups: group 1, patients who received a 2 ml intravenous dose of 5 mg/ml bromopride and group 2, patients who received a 2 ml intravenous dose of 0.9% sodium chloride (placebo), both 20 minutes before the dye injection. Cases of nausea were observed during and after the examination.

RESULTS:

352 patients were enrolled, 176 in each group. Cases of nausea were observed in 12 (6.8%) patients of the bromopride group and in 11 (6.3%) patients of the placebo group (p<0.829 - relative risk=1.05).

CONCLUSION:

Bromopride did not prevent the occurrence of nausea in fluorescein angiography, when compared with a placebo.

• Authors: Rodrigo Pessoa Cavalcanti Lira, Luiz Felipe Lynch de Moraes, Mauro de Oliveira Júnior, Antônio Luiz Barbosa de Melo, Mirelle Souza Leão Vasconcelos
• Journal: Arquivos brasileiros de oftalmologia (Arq Bras Oftalmol) 2007 Jan-Feb Vol. 70 Issue 1 Pg. 105-8 ISSN: 0004-2749 [Print] Brazil
• PMID: 17505728 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Antiemetics
• bromopride
• Metoclopramide

Topics

• Antiemetics (therapeutic use)
• Double-Blind Method
• Female
• Fluorescein Angiography (adverse effects)
• Humans
• Male
• Metoclopramide (analogs & derivatives, therapeutic use)
• Middle Aged
• Nausea (etiology, prevention & control)
• Treatment Outcome