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Cancer chemopreventive effects of cycloartane-type and related triterpenoids in in vitro and in vivo models.

Abstract
Forty-eight natural and semisynthetic cycloartane-type and related triterpenoids have been evaluated for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells as a primary screening test for anti-tumor promoters. In addition, these triterpenoids have been tested for their inhibitory effects on activation of (+/-)-(E)-methtyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor, as a primary screening test for anti-tumor initiators. All of the compounds tested exhibited inhibitory effects on both EBV-EA and NOR 1 activation. Six of these compounds having a C-24 hydroxylated side chain, viz., (24R)-cycloart-25-ene-3beta,24-diol (9), (24R)-cycloartane-3beta,24,25-triol (11), (24S)-cycloartane-3beta,24,25-triol (12), (24xi)-24-methylcycloartane-3beta,24,241-triol (14), (24xi)-241-methoxy-24-methylcycloartane-3beta,24-diol (15), and (24xi)-24,25-dihydroxycycloartan-3-one (27), showed higher inhibitory effects than the others tested on both EBV-EA (IC50 values of 6.1-7.4 nM) and NOR 1 activation. Furthermore, compounds 14 and 15 exhibited inhibitory effects on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.
AuthorsTakashi Kikuchi, Toshihiro Akihisa, Harukuni Tokuda, Motohiko Ukiya, Kenji Watanabe, Hoyoku Nishino
JournalJournal of natural products (J Nat Prod) Vol. 70 Issue 6 Pg. 918-22 (Jun 2007) ISSN: 0163-3864 [Print] United States
PMID17503850 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anticarcinogenic Agents
  • Antigens, Viral
  • Epstein-Barr virus early antigen
  • Triterpenes
  • cycloartane
  • Tetradecanoylphorbol Acetate
Topics
  • Algorithms
  • Animals
  • Anticarcinogenic Agents (chemistry, pharmacology)
  • Antigens, Viral (drug effects)
  • Dose-Response Relationship, Drug
  • Mice
  • Models, Biological
  • Molecular Structure
  • Skin (drug effects)
  • Tetradecanoylphorbol Acetate (pharmacology)
  • Time Factors
  • Triterpenes (chemistry, pharmacology)

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