Abstract | BACKGROUND:
Cyanide-poisoned patients are potential organ donors provided that organs are not damaged by the poison or by antidotal treatment. CASE STUDY: A patient with third-degree burns and smoke inhalation-associated cyanide poisoning confirmed by measurements of whole blood cyanide was found in cardiac arrest and administered epinephrine and hydroxocobalamin (5 g + 5 g). Cardiac activity resumed, but the patient was declared brain dead on the third day of hospitalization when coma deteriorated to a shock state with refractory hypoxemia. Kidneys, heart, and liver were removed and transplanted into four patients. Gross pre- transplantation inspection of the donor organs and renal histology showed no evidence that hydroxocobalamin caused organ toxicity. Donor organs functioned normally through follow-up periods of several months. CONCLUSION:
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Authors | J L Fortin, M Ruttimann, G Capellier, A Bigorie, S Ferlicot, E Thervet |
Journal | Clinical toxicology (Philadelphia, Pa.)
(Clin Toxicol (Phila))
2007 Jun-Aug
Vol. 45
Issue 5
Pg. 468-71
ISSN: 1556-3650 [Print] England |
PMID | 17503248
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antidotes
- Cyanides
- Hydroxocobalamin
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Topics |
- Antidotes
(therapeutic use)
- Cyanides
(blood, poisoning)
- Female
- Heart Arrest
(drug therapy)
- Heart Transplantation
- Humans
- Hydroxocobalamin
(therapeutic use)
- Kidney Transplantation
- Liver Transplantation
- Male
- Middle Aged
- Tissue Donors
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