[Efficacy of various antioxidants in experimental ischemia and myocardial infarct in the rat].

Abstract

Complex of vitamins E and C showed the most effective antinecrotic action in rats with simulated myocardial infarction in series of antioxidants studied: ascorbate, alpha-tocopherol, quercetine, derivatives of o-benzoquinone OBQ2 and OBQ3. Stabilization of lipid peroxidation in cardiomyocytes, increase in biomembranes stability and absence of distinct alterations in the antioxidative enzymatic system were found in rats with ischemia and myocardial infarction after treatment with the complex. Protective effect of the vitamins E and C complex was realised via antiradical mechanism.

• Authors: G S Poliukhovich, L P Vasil'eva, G T Maslova, T L Boboriko, S D Speranskiĭ
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1991 Jul-Aug Vol. 37 Issue 4 Pg. 54-6 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Effektivnost' nekotorykh antioksidantov pri éksperimental'nykh ishemii i infarkte miokarda u krys.
• PMID: 1750212 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Benzoquinones
• Hemoglobins
• Vitamin E
• quinone
• Quercetin
• Catalase
• Ascorbic Acid

Topics

• Animals
• Antioxidants
• Ascorbic Acid (therapeutic use)
• Benzoquinones (therapeutic use)
• Catalase (blood)
• Coronary Disease (drug therapy)
• Erythrocytes (enzymology)
• Hemoglobins (analysis)
• Myocardial Infarction (drug therapy)
• Quercetin (therapeutic use)
• Rats
• Rats, Inbred Strains
• Vitamin E (therapeutic use)