The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum.

Abstract

The anti-androgenic activity of the ethanol extract of the fruiting body of Ganoderma lucidum has been previously reported. Ganoderol B with 5alpha-reductase inhibitory activity and the ability to bind to androgen receptor (AR) can inhibit androgen-induced LNCaP cell growth and suppress regrowth of the ventral prostate induced by testosterone in rats. The down-regulation of AR signaling by ganoderol B provides an important mechanism for its anti-androgenic activity. In view of the fact that PSA (prostatic specific antigen, a well-accepted prognostic indicator of prostate cancer) is down-regulated, an important implication of this study is that ganoderol B intervention strategy aimed at toning down the amplitude of androgen signaling could be helpful in controlling morbidity of prostate cancer. In conclusion, our result suggests that ganoderol B might be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor.

• Authors: Jie Liu, Kuniyoshi Shimizu, Fumiko Konishi, Shoichiro Kumamoto, Ryuichiro Kondo
• Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 15 Issue 14 Pg. 4966-72 (Jul 15 2007) ISSN: 0968-0896 [Print] England
• PMID: 17499997 (Publication Type: Journal Article)

Chemical References

• Androgen Antagonists
• Androgens
• RNA, Messenger
• Triterpenes
• ganoderol B
• Testosterone
• Prostate-Specific Antigen

Topics

• Androgen Antagonists (chemistry, isolation & purification, pharmacology)
• Androgens (genetics, metabolism)
• Animals
• Cell Line, Tumor
• Gene Expression Regulation (drug effects)
• Humans
• Male
• Molecular Structure
• Prostate (drug effects, growth & development)
• Prostate-Specific Antigen (genetics)
• RNA, Messenger (genetics)
• Rats
• Reishi (chemistry)
• Testosterone (pharmacology)
• Triterpenes (chemistry, isolation & purification, pharmacology)