Abstract | OBJECTIVE:
Cardiopulmonary bypass (CPB)-induced acute liver injury is a life-threatening complication after cardiac surgery and is thought to be associated with inflammatory response and acute-phase response (APR). Recombinant human growth hormone (rhGH) can modulate the APR and inflammatory response. Here, we tested the protective effect of GH on CPB-induced liver injury in the rat. METHODS: Adult male Sprague-Dawley rats (group G, received 2.5 mg/kg of rhGH intramuscularly at 8a.m. every 24h for 3 days and just before the initiation of CPB; group C served as control) underwent CPB (120 min, 120 ml/kg per minute, 34 degrees C) and were killed 3h after the termination of CPB. RESULTS: CONCLUSIONS: These results suggest that GH administration in rats seems to play a preventative role in acute liver injury associated with CPB via the decrease in acute-phase proteins, proinflammatory cytokines TNF-alpha and IL-1beta, and hepatocyte apoptosis, which is associated with increase in constitutive hepatic proteins, total liver protein content, and hepatocyte proliferation.
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Authors | Yong An, Ying-Bin Xiao |
Journal | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
(Eur J Cardiothorac Surg)
Vol. 31
Issue 6
Pg. 1037-43
(Jun 2007)
ISSN: 1010-7940 [Print] Germany |
PMID | 17498965
(Publication Type: Journal Article)
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Chemical References |
- Acute-Phase Proteins
- Carrier Proteins
- Cytokines
- Insulin-Like Growth Factor Binding Protein 3
- Recombinant Proteins
- Human Growth Hormone
- Insulin-Like Growth Factor I
- somatotropin-binding protein
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Topics |
- Acute Disease
- Acute-Phase Proteins
(analysis)
- Acute-Phase Reaction
(immunology)
- Animals
- Apoptosis
(immunology)
- Cardiopulmonary Bypass
(adverse effects)
- Carrier Proteins
(blood)
- Cell Division
(immunology)
- Cytokines
(blood)
- Disease Models, Animal
- Human Growth Hormone
(administration & dosage, blood)
- Immunohistochemistry
(methods)
- Injections, Intramuscular
- Insulin-Like Growth Factor Binding Protein 3
(blood)
- Insulin-Like Growth Factor I
(analysis)
- Liver
(immunology, pathology, physiopathology)
- Liver Diseases
(etiology, immunology, prevention & control)
- Male
- Rats
- Rats, Sprague-Dawley
- Recombinant Proteins
(administration & dosage, blood)
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