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Achievement of immune tolerance in a patient with haemophilia B and inhibitory antibodies, complicated by an anaphylactoid reaction.

Abstract
We describe a young boy with severe haemophilia B who developed inhibitory antibodies and an anaphylactoid reaction to factor IX. Immune tolerance was achieved by desensitisation with escalating doses of factor IX followed by the Malmö regimen.
AuthorsN S Curry, S A Misbah, P L F Giangrande, D M Keeling
JournalHaemophilia : the official journal of the World Federation of Hemophilia (Haemophilia) Vol. 13 Issue 3 Pg. 328-30 (May 2007) ISSN: 1351-8216 [Print] England
PMID17498084 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies
  • Factor IX
Topics
  • Anaphylaxis (immunology)
  • Antibodies (immunology)
  • Child, Preschool
  • Drug Administration Schedule
  • Factor IX (adverse effects)
  • Hemophilia B (drug therapy, immunology)
  • Humans
  • Immune Tolerance
  • Male
  • Treatment Outcome

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