Triphenylantimony(V) derivative,
Ph(3)Sb(OPr(i)) [SC(6)H(4)N : C(CH(3))CH(2)C(O)CH(3)], 1b, and the corresponding
benzothiazoline ligand [1, 2], HNC(6)H(4)SC(CH(3))CH(2)C(O)CH(3), 1a, have been tested for their effects on the reproductive system of male albino rats. The
oral administration of both 1a and 1b at the dose level of 10 mg/rat/day produced significant reduction in the weights of testes, epididymides, seminal vesicles, and ventral prostate. Significant decrease in sperm motility as well as in sperm density resulted in 100%
sterility. Significant (P < .01) alterations were also found in biochemical parameters of reproductive organs in treated male rats as compared to the control group. Production of preleptotene, pachytene, and secondary spermatocytes was decreased by 42%, 43%, 39%, and by 44%, 49%, 55% in the
ligand, 1a, and organoantimony(V) derivative, 1b, treated rats, respectively. These results indicate that both compounds 1a and 1b are antispermatogenic in nature and on
oral administration in male rats, and finally caused
sterility. A comparison indicates that the organoantimony(V) derivative 1b is more effective pertaining to its antispermatogenic activity than the corresponding
ligand 1a.