[Nedaplatin (NDP)-combination therapy (NDP/5-FU,NDP/S-1) for oral cancer].

Abstract

PURPOSE:

The present study evaluated the efficacy and safety of nedaplatin-combination therapy (NDP/5-FU [5-FU arm] or NDP/S-1 [S-1 arm] ) for the treatment of oral squamous cell carcinoma.

PATIENTS AND METHOD:

Previously non-treated oral squamous cell carcinoma patients were eligible. Patients received 5-FU 600 mg/m(2)iv, as a 24-hour infusion (day 1 to 5) followed by NDP 80 to 100 mg/m(2) iv (day 1), or S-1 60 to 80 mg/m(2) orally twice a day (day 1 to 14) followed by NDP 80 mg/m(2) iv (day 8) every 28 days for one or two cycles.

RESULTS:

In total, 32 patients (18 in the 5-FU arm, 14 in the S-1 arm) were enrolled. Twenty patients were male and 12 were female. Median age was 57 years (range 20 years to 87 years). Thirty-one patients had a performance status (PS) oF 0, and 1 patient had a PS 1. Three patients were stage I, 12 stage III, and 12 were stage IV. The overall response rate was 69% (5-FU arm,72%;S-1 arm,64%). Two patients achieved a complete response, 20 patients a partial response, and 10 patients had no change. Grade 3 leucopenia, grade 3 and 4 thrombocytopenia and liver injury occurred in 6% (one in the 5-FU arm, and one in the S-1 arm), 9% (two in the 5-FU arm, and one in the S-1 arm), and 3% (one in the 5-FU arm), respectively. No other severe toxicities were observed.

RESULTS:

Response rate and toxicities were similar in both arms. However, the psychosocial stress on patients in the S-1 arm was reduced compared to that in the 5-FU arm, which required hospitalization for a longer period. The outcome in the present study needs further investigation.

• Authors: Yasubumi Maruoka, Tomohiro Ando, Yosuke Ogiuchi, Hideki Ogiuchi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 34 Issue 5 Pg. 713-7 (May 2007) ISSN: 0385-0684 [Print] Japan
• PMID: 17496443 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Organoplatinum Compounds
• S 1 (combination)
• Tegafur
• Oxonic Acid
• nedaplatin
• Fluorouracil

Topics

• Administration, Oral
• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Chemotherapy, Adjuvant
• Drug Administration Schedule
• Drug Combinations
• Fluorouracil (administration & dosage)
• Humans
• Infusions, Intravenous
• Leukopenia (chemically induced)
• Male
• Middle Aged
• Mouth Neoplasms (drug therapy)
• Nausea (chemically induced)
• Organoplatinum Compounds (administration & dosage)
• Oxonic Acid (administration & dosage)
• Tegafur (administration & dosage)
• Thrombocytopenia (chemically induced)
• Vomiting, Anticipatory (etiology)