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Exercise pretraining protects against cerebral ischaemia induced by heat stroke in rats.

AbstractBACKGROUND:
In the rat brain, heat-stroke-induced damage to cerebral neurons is attenuated through heat-shock-induced overexpression of heat-shock protein 72 (HSP72).
OBJECTIVE:
To ascertain whether progressive exercise preconditioning induces HSP72 expression in the rat brain and prevents heat-stroke-induced cerebral ischaemia and injury.
METHODS:
Male Wistar rats were randomly assigned to either a sedentary group or an exercise group. Those in the exercise group progressively ran on a treadmill 5 days/week, for 30-60 min/day at an intensity of 20-30 m/min for 3 weeks. The effects of heat stroke on mean arterial pressure, cerebral blood flow, brain ischaemia markers (glutamate, lactate/pyruvate ratio and nitric oxide), a cerebral injury marker (glycerol) and brain neuronal damage score in the preconditioned animals were compared with effects in unexercised controls. Heat stroke was induced by exposing urethane-anaesthetised animals to a temperature of 43 degrees C for 55 min, which caused the body temperature to reach 42 degrees C.
RESULTS:
Three weeks of progressive exercise pretreatment induced HSP72 preconditioning in the brain and conferred significant protection against heat-stroke-induced hyperthermia, arterial hypotension, cerebral ischaemia and neuronal damage; it also prolonged survival.
CONCLUSIONS:
Exercise for 3 weeks can improve heat tolerance as well as attenuate heat-stroke-induced cerebral ischaemia in rats. The maintenance of mean arterial pressure and cerebral blood flow at appropriate levels in the rat brain may be related to overexpression of HSP72.
AuthorsYu-Wen Chen, Sheng-Hsien Chen, Willy Chou, Yi-Ming Lo, Ching-Hsia Hung, Mao-Tsun Lin
JournalBritish journal of sports medicine (Br J Sports Med) Vol. 41 Issue 9 Pg. 597-602 (Sep 2007) ISSN: 1473-0480 [Electronic] England
PMID17496074 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • HSP72 Heat-Shock Proteins
Topics
  • Animals
  • Blotting, Western
  • Body Temperature (physiology)
  • Brain Ischemia (prevention & control)
  • Cerebrovascular Circulation (physiology)
  • HSP72 Heat-Shock Proteins (metabolism)
  • Heart Rate (physiology)
  • Heat Stroke (etiology, physiopathology)
  • Male
  • Neurons (pathology)
  • Physical Conditioning, Animal (physiology)
  • Random Allocation
  • Rats
  • Rats, Wistar

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