[Effect of therapy with atorvastatin on parameters of postprandial lipemia and factors of inflammation in patients with ischemic heart disease].

Abstract

Reaction of parameters of lipid transport system to standard fat load (J.Patsch method), C-reactive protein (CRP) and fibrinogen levels were studied in 30 patients with ischemic heart disease before and after 3 months of therapy with atorvastatin (10 mg/day). Atorvastatin therapy resulted in 25, 34, 17 and 16% lowering of concentrations of total cholesterol (CH), low density lipoprotein CH, triglycerides (TG), and apolipoprotein (apo) B, respectively, 6 and 9% elevation of high density lipoprotein CH and apo A-1 levels, respectively. Moreover atorvastatin improved although not completely normalized parameters of postprandial lipemia: significant lowering of baseline (-17%), 3 (-19%) and 6 hour (-14%) post load TG levels was noted. However relative TG elevation from baseline level to 3 and 6 hours after fat load did not change (+100 and 148% before, +95 and 156% after treatment, respectively). Changes of CRP (-22%) and fibrinogen (-8%) were not significant (p>0.05).

• Authors: E Iu Samoĭlenko, V G Naumov, M G Tvorogova, M V Ezhov, I V Sergienko, V V Kukharchuk
• Journal: Kardiologiia (Kardiologiia) Vol. 47 Issue 2 Pg. 4-8 ( 2007) ISSN: 0022-9040 [Print] Russia (Federation)
• PMID: 17495815 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Anticholesteremic Agents
• Heptanoic Acids
• Lipids
• Pyrroles
• Fibrinogen
• C-Reactive Protein
• Atorvastatin

Topics

• Adult
• Anticholesteremic Agents (pharmacology, therapeutic use)
• Atorvastatin
• C-Reactive Protein (analysis)
• Female
• Fibrinogen (analysis)
• Heptanoic Acids (pharmacology, therapeutic use)
• Humans
• Hyperlipidemias (complications, drug therapy)
• Inflammation (complications, drug therapy)
• Lipids (blood)
• Male
• Myocardial Ischemia (complications)
• Postprandial Period (drug effects)
• Pyrroles (pharmacology, therapeutic use)
• Treatment Outcome