Abstract |
1-beta-D-Arabinofuranosylcytosine-5'-stearylphosphate ( fosteabine) was administered orally to patients with myelodysplastic syndromes (MDS); refractory anemia with excess of blasts ( RAEB), RAEB in transformation, acute leukemia derived from RAEB and chronic myelomonocytic leukemia, in an early phase II study in a multi-institutional study. Among 62 evaluable patients, 2 patients achieved a complete remission, 6 a good response and 8 partial response by daily oral administration of 100-200 mg of fosteabine. The overall response rate was 25.8%. The response rates were almost the same among the four subtypes of MDS. Responses were reached 2-23 weeks (median, 8 weeks) after the start of therapy and continued for 3-50 weeks (median, 10 weeks). Major side effects were myelosuppression and gastrointestinal toxicities. In spite of the disadvantages, such as unpredictable absorption, this newly developed orally administrable cytarabine analogue will be a useful drug in the treatment of MDS.
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Authors | R Ohno, N Tatsumi, M Hirano, K Imai, H Mizoguchi, T Nakamura, M Kosaka, K Takatsuki, T Yamaya, K Toyama |
Journal | Oncology
(Oncology)
Vol. 48
Issue 6
Pg. 451-5
( 1991)
ISSN: 0030-2414 [Print] Switzerland |
PMID | 1749580
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Arabinonucleotides
- 1-arabinofuranosylcytosine-5'-stearylphosphate
- Cytidine Monophosphate
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Arabinonucleotides
(adverse effects, therapeutic use)
- Cytidine Monophosphate
(adverse effects, analogs & derivatives, therapeutic use)
- Dose-Response Relationship, Drug
- Drug Evaluation
- Female
- Humans
- Male
- Middle Aged
- Myelodysplastic Syndromes
(drug therapy)
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