[Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia].

Abstract	The study was purposed to investigate the polymorphism of killer cell immunoglobulin-like receptor (KIR) gene of the patients with leukemia and to explore the correlation between the KIR gene and susceptibility of leukemia. The KIR genotype of 50 patients with leukemia and 60 healthy controls in northern. Hans were analyzed by PCR-SSP. The results indicated that the present known 18 KIR genes were detected and identified. The frequencies of KIR 3DL3, 3DL2 and 2DL4 were 100% in all subjects, with the most frequent genotype KIR 3DP1 (0.86) followed by 2DP1, 2DL3, 3DL1, 2DL1, 3DS1, 2DL5, 2DS4, 2DS2, 1D, 2DS5, 2DL2, 2DS1, 2DS3 and 3DP1v in leukemia successively. Compared with the control, the KIR 3DL1 (0.60) and 2DL1 (0.57) were significantly lower in the leukemia patient group than that in the control group (1.00) (P < 0.01). It is concluded that the polymorphism of KIR gene is associated with susceptibility of leukemia in Hans. There may be a negative correlation between pathogenesis of leukemia and KIR 3DL1, KIR 3DS1, KIR 2DL1, KIR 2DL5 genes.
Authors	A-Mei Chen, Xiao-Ming Guo, Wen-Ying Yan, Song-Mei Xie, Na Zhu, Xin-Dang Wang, Ri Xu, Qing-Ping Liu
Journal	Zhongguo shi yan xue ye xue za zhi (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 15 Issue 1 Pg. 35-8 (Feb 2007) ISSN: 1009-2137 [Print] China
PMID	17490516 (Publication Type: English Abstract, Journal Article)
Chemical References	Receptors, Immunologic Receptors, KIR Receptors, KIR2DL1 Receptors, KIR2DL3 Receptors, KIR2DL4 Receptors, KIR3DL1 Receptors, KIR3DL2 Receptors, KIR3DS1
Topics	Adolescent Adult Child, Preschool Female Genetic Predisposition to Disease (genetics) Genotype Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive (genetics) Male Middle Aged Polymorphism, Genetic Precursor Cell Lymphoblastic Leukemia-Lymphoma (genetics) Receptors, Immunologic (genetics) Receptors, KIR Receptors, KIR2DL1 Receptors, KIR2DL3 Receptors, KIR2DL4 Receptors, KIR3DL1 Receptors, KIR3DL2 Receptors, KIR3DS1

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