Tissue angiotensin-converting enzyme in patients with various clinical forms of psoriasis.

• Abstract: Tissue angiotensin-converting enzyme (ACE) was measured in 60 patients with psoriasis and in 20 healthy individuals. According to clinical forms of psoriasis, patients were further divided into three groups: psoriasis with solitary lesions (n=20), psoriasis with multiple disseminated lesions (n=20) and erythrodermic psoriasis (n=20). The tissue ACE activity was determined before and after therapy, by the spectrophotometric method using hippuryl-l-histidyl-l-leucine as a substrate. The enzyme activity is expressed in units: 1 U corresponds to 1 nmol of hippuric acid released by hydrolysis of hippuryl-l-histidyl-l-leucine per minute and 50 mg of the tissue. Before therapy, tissue ACE activity was significantly increased in patients with psoriasis (4,14+/-0,34; X+/-SEM) in comparison to healthy individuals (1,86+/-0,16). The greatest increase in tissue ACE activity was observed in patients with erythrodermic psoriasis (4,72+/-0,65), followed by those with multiple disseminated lesions (4,24+/-0,63) and solitary psoriatic lesions (3,47+/-0,48). After therapy, serum ACE activity was significantly decreased in all clinical forms of the disease. Determination of tissue ACE activity might be a good non-specific parameter for assessment therapeutic effects.
• Authors: Jasminko Huskić, Faruk Alendar (Affiliation: Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo, Cekalusa 90, 71000 Sarajevo, Bosnia and Herzegovina.)
• Journal: Bosnian journal of basic medical sciences / Udruženje basičnih mediciniskih znanosti = Association of Basic Medical Sciences (Bosn J Basic Med Sci) Vol. 7 Issue 2 Pg. 103-6 (May 2007) ISSN: 1512-8601 [Print] Bosnia and Hercegovina
• PMID: 17489742 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Biological Markers
• Dermatologic Agents
• Methotrexate
• Peptidyl-Dipeptidase A

Topics

• Adult
• Biological Markers (metabolism)
• Biopsy
• Case-Control Studies
• Dermatologic Agents (therapeutic use)
• Diagnosis, Differential
• Female
• Gene Expression Regulation, Enzymologic
• Humans
• Male
• Methotrexate (therapeutic use)
• Middle Aged
• Peptidyl-Dipeptidase A (genetics, metabolism)
• Photochemotherapy (methods)
• Psoriasis (drug therapy, enzymology, pathology)
• Skin (enzymology, pathology)