T-cell depletion prevents from bronchiolitis obliterans and bronchiolitis obliterans with organizing pneumonia after allogeneic hematopoietic stem cell transplantation with related donors.

Abstract	Bronchiolitis obliterans (BO) and bronchiolitis obliterans organizing pneumonia (BOOP) are late-onset non-infectious pulmonary complications (LONIPCs) following allogeneic hematopoietic stem cell transplantation (HSCT). In the present study 10 of 197 conventionally prepared stem cell recipients developed BOOP after 365 days and 6 patients developed BO 333 days post-transplant. No BOOP or BO was diagnosed following T-cell depletion (p<0.05). Chronic GVHD was ascertained in all BOOP patients and appeared significantly (p<0,001) more frequent in the conventional transplant group. The data confirm a strong association between T-cell activity, chronic GVHD, BO and BOOP and point out the impact of T lymphocytes in the pathomechanism of BOOP.
Authors	Markus Ditschkowski, Ahmet H Elmaagacli, Rudolf Trenschel, Rudolf Peceny, Michael Koldehoff, Claudia Schulte, Dietrich W Beelen
Journal	Haematologica (Haematologica) Vol. 92 Issue 4 Pg. 558-61 (Apr 2007) ISSN: 1592-8721 [Electronic] Italy
PMID	17488669 (Publication Type: Comparative Study, Evaluation Study, Journal Article)
Chemical References	NOD2 protein, human Nod2 Signaling Adaptor Protein TLR4 protein, human Toll-Like Receptor 4
Topics	Adult Aged Bone Marrow Transplantation (adverse effects) Bronchiolitis Obliterans (etiology, genetics, immunology, prevention & control) Cryptogenic Organizing Pneumonia (etiology, genetics, immunology, prevention & control) Female Graft vs Host Disease (etiology, prevention & control) Humans Kaplan-Meier Estimate Lymphocyte Depletion (statistics & numerical data) Lymphocyte Transfusion Male Middle Aged Nod2 Signaling Adaptor Protein (genetics) Peripheral Blood Stem Cell Transplantation (adverse effects) Postoperative Complications (etiology, mortality, prevention & control) Proportional Hazards Models Respiratory Insufficiency (mortality) Retrospective Studies Sex Factors T-Lymphocytes (immunology, transplantation) Tissue Donors Toll-Like Receptor 4 (genetics) Transplantation Conditioning (adverse effects) Transplantation, Homologous

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