Abstract | PURPOSE: To examine the clinical picture and molecular genetics of 12 Norwegian families with autosomal dominant retinitis pigmentosa (adRP) in order to achieve a genotype-phenotype correlation. METHODS: RESULTS: Mutations were found only in the RHO gene. Seven families were given a diagnosis of classical RP. Two of them had novel mutation 1003delG, and one family had the mutation V345M. Four families had pericentral retinal dystrophy (PRD), two families with the mutation A164V and one with novel mutation I179F. One family was given a diagnosis of central and pericentral retinal dystrophy (CPRD), a special type of cone/rod dystrophy, and no mutation was found. CONCLUSIONS: Six of 12 families had an RHO mutation. The mutation V345M and the novel mutation 1003delG both caused classical RP, the former indicating the most unfavourable prognosis. Two of the families with PRD had the A164V mutation with a favourable prognosis, whereas the novel mutation I179F caused PRD with extremely variable expressivity.
|
Authors | Jan Grøndahl, Ruth Riise, Arvid Heiberg, Trond Leren, Terje Christoffersen, Ragnheidur Bragadottir |
Journal | Acta ophthalmologica Scandinavica
(Acta Ophthalmol Scand)
Vol. 85
Issue 3
Pg. 287-97
(May 2007)
ISSN: 1395-3907 [Print] Denmark |
PMID | 17488458
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Eye Proteins
- Intermediate Filament Proteins
- Membrane Glycoproteins
- Microtubule-Associated Proteins
- Nerve Tissue Proteins
- PRPH protein, human
- PRPH2 protein, human
- Peripherins
- RP1 protein, human
- Rhodopsin
- IMP Dehydrogenase
- IMPDH1 protein, human
|
Topics |
- Adolescent
- Adult
- Aged
- DNA Mutational Analysis
- Dark Adaptation
- Electroretinography
- Eye Proteins
(genetics)
- Female
- Follow-Up Studies
- Frameshift Mutation
- Genes, Dominant
- Humans
- IMP Dehydrogenase
(genetics)
- Intermediate Filament Proteins
(genetics)
- Male
- Membrane Glycoproteins
(genetics)
- Microtubule-Associated Proteins
- Middle Aged
- Mutation, Missense
- Nerve Tissue Proteins
(genetics)
- Norway
(epidemiology)
- Pedigree
- Peripherins
- Phenotype
- Photography
- Polymerase Chain Reaction
- Retinitis Pigmentosa
(diagnosis, epidemiology, genetics)
- Rhodopsin
(genetics)
- Visual Fields
|