Abstract | RATIONALE: MATERIALS AND METHODS: To test this hypothesis, rats were administered lamotrigine (10 mg kg(-1) day(-1)) or vehicle intragastrically once daily for 42 days. In the unanesthetized rat, [1-(14)C] arachidonic acid was infused intravenously and arterial blood plasma was sampled until the animal was killed at 5 min, and its microwaved brain was subjected to chemical and radiotracer analysis. RESULTS: CONCLUSION:
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Authors | Ho-Joo Lee, Jagadeesh S Rao, Lisa Chang, Stanley I Rapoport, Richard P Bazinet |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 193
Issue 4
Pg. 467-74
(Sep 2007)
ISSN: 0033-3158 [Print] Germany |
PMID | 17487474
(Publication Type: Journal Article, Research Support, N.I.H., Intramural)
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Chemical References |
- Acyl Coenzyme A
- Antimanic Agents
- Phospholipids
- Triazines
- Arachidonic Acid
- gamma-Aminobutyric Acid
- Lamotrigine
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Topics |
- Acyl Coenzyme A
(metabolism)
- Animals
- Antimanic Agents
(pharmacology)
- Arachidonic Acid
(metabolism)
- Bipolar Disorder
(drug therapy)
- Brain
(drug effects, metabolism)
- Disease Models, Animal
- Down-Regulation
- Lamotrigine
- Male
- Phospholipids
(metabolism)
- Random Allocation
- Rats
- Rats, Inbred F344
- Triazines
(pharmacology)
- gamma-Aminobutyric Acid
(drug effects, metabolism)
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