| Abstract | Left ventricular (LV) hypertrophy is related to blood pressure level and neurohormonal factors. The authors previously demonstrated that arterial norepinephrine levels predict LV mass in middle-aged men who developed hypertension through 20 years. The aim of this 20-year prospective study was to investigate arterial vasopressin, aldosterone, and renin as long-term predictors of LV mass. Normotensives (n=17), subjects who developed hypertension (n=17), and sustained hypertensives (n=22) were compared at baseline (42 years) and at follow-up (62 years). There were no significant differences in baseline vasopressin, aldosterone, or renin levels. The group with sustained hypertension had more LV hypertrophy (P=.025) at follow-up. Among new hypertensives, multiple regression analysis demonstrated that baseline arterial vasopressin (beta-0.53; P=.041) and aldosterone (beta-0.56;P=.032) independently explained LV mass index (R(2)=0.85; P=.035). In conclusion, baseline arterial vasopressin and aldosterone, but not renin, appear to predict LV mass in middle-aged men who developed hypertension over a 20-year period. |
| Authors | Arne H Strand, Helga Gudmundsdottir, Eigil Fossum, Ingrid Os, Reidar Bjørnerheim, Sverre E Kjeldsen
(Affiliation: Department of Cardiology, Ullevaal University Hospital, Oslo, Norway. a.h.strand at medisin.uio.no)
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| Journal | Journal of clinical hypertension (Greenwich, Conn.)
(J Clin Hypertens (Greenwich))
Vol. 9
Issue 5
Pg. 365-71
(May 2007)
ISSN: 1524-6175 United States |
| PMID | 17485972
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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| Chemical References |
- Antihypertensive Agents
- Biological Markers
- Vasopressins
- Aldosterone
- Renin
|
| Topics |
- Adult
- Aldosterone
(blood)
- Analysis of Variance
- Antihypertensive Agents
(therapeutic use)
- Arteries
- Biological Markers
(blood)
- Blood Pressure
(drug effects)
- Cross-Sectional Studies
- Echocardiography
- Follow-Up Studies
- Heart Rate
(drug effects)
- Humans
- Hypertension
(blood, complications, drug therapy, physiopathology)
- Hypertrophy, Left Ventricular
(blood, complications, physiopathology, ultrasonography)
- Male
- Middle Aged
- Pilot Projects
- Predictive Value of Tests
- Prospective Studies
- Regression Analysis
- Renin
(blood, drug effects)
- Time Factors
- Vasopressins
(blood, drug effects)
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