Abstract | BACKGROUND: METHODS: Male KK-A(y) mice were treated with TAK-536 or candesartan at doses of 0.0005%, 0.001%, and 0.005% in laboratory chow for 2 weeks. Results of an oral glucose tolerance test (OGTT) and tissue glucose uptake were examined. Expression of markers for insulin resistance and adipocyte differentiation was measured by quantitative reverse transcriptase-polymerase chain reaction. RESULTS: CONCLUSIONS:
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Authors | Masaru Iwai, Rui Chen, Yoshimi Imura, Masatsugu Horiuchi |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 20
Issue 5
Pg. 579-86
(May 2007)
ISSN: 0895-7061 [Print] United States |
PMID | 17485025
(Publication Type: Journal Article)
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Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- Benzimidazoles
- Biphenyl Compounds
- Oxadiazoles
- Tetrazoles
- Tumor Necrosis Factor-alpha
- azilsartan
- Glucose
- candesartan
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Topics |
- Adipocytes
(drug effects, physiology)
- Adipose Tissue
(cytology, drug effects)
- Angiotensin II Type 1 Receptor Blockers
(pharmacology, therapeutic use)
- Animals
- Benzimidazoles
(pharmacology, therapeutic use)
- Biphenyl Compounds
- Blood Pressure
(drug effects)
- Body Weight
(drug effects)
- Cell Differentiation
- Cell Size
(drug effects)
- Eating
(drug effects)
- Glucose
(metabolism)
- Glucose Intolerance
(drug therapy)
- Insulin Resistance
- Male
- Mice
- Muscle, Skeletal
(metabolism)
- Oxadiazoles
(pharmacology, therapeutic use)
- Tetrazoles
(pharmacology)
- Tumor Necrosis Factor-alpha
(metabolism)
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