Abstract | BACKGROUND: METHODS: We investigated the hypothesis that the CRABP2 gene is involved in the regulation of lipid metabolism. Using the promoter -394T>C polymorphism of the CRABP2 gene, we performed association studies in three different cohorts: 299 healthy males, 182 HIV-infected patients and 151 patients with familial hypercholesterolemia (FH). All cholesterol measurements were performed in the absence of any lipid-lowering agents. ANOVA was performed on data adjusted for age, body mass index (BMI), gender, and use of protease inhibitors. RESULTS: The frequency of the C allele was 0.03 in the three groups. Among healthy males, carriers of the C allele had 9% higher total plasma cholesterol (p=0.027) and 13% higher low-density lipoprotein cholesterol ( LDL-C) concentrations (p=0.020). In HIV-infected patients, multivariate analysis of four measures over a 1-year period showed that carriers of the C allele had significantly higher LDL-C of between 10% and 31% (p=0.001) compared with non-carriers of the allele. FH patients who were carriers of the C allele had 16% higher LDL-C (p=0.038). The C allele was significantly over-represented among hypercholesterolemic patients (p=0.001). CONCLUSIONS: Our results show that the CRABP2 gene, a member of the retinoid signaling pathway, is associated with increased plasma LDL-C concentrations.
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Authors | Juliana Salazar, Montse Guardiola, Raimon Ferré, Blai Coll, Carlos Alonso-Villaverde, Brigitte M Winklhofer-Roob, Edmond Rock, Joan D Fernández-Ballart, Fernando Civeira, Miguel Pocoví, Lluís Masana, Josep Ribalta |
Journal | Clinical chemistry and laboratory medicine
(Clin Chem Lab Med)
Vol. 45
Issue 5
Pg. 615-20
( 2007)
ISSN: 1434-6621 [Print] Germany |
PMID | 17484622
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, LDL
- Receptors, Retinoic Acid
- retinoic acid binding protein II, cellular
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Topics |
- Adult
- Aged
- Case-Control Studies
- Cholesterol, LDL
(blood)
- Gene Frequency
- HIV Infections
(metabolism)
- Humans
- Hyperlipoproteinemia Type II
(metabolism)
- Lipid Metabolism
(genetics)
- Male
- Middle Aged
- Polymorphism, Genetic
- Promoter Regions, Genetic
(genetics)
- Receptors, Retinoic Acid
(genetics)
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