[The results of combined treatment (surgery and postoperative radiotherapy) for tongue cancer and prognostic factors].

Abstract

OBJECTIVES:

We evaluated the results of surgical treatment and postoperative radiotherapy and prognostic factors in patients with primary tongue carcinoma.

PATIENTS AND METHODS:

The study included 60 patients (31 males, 29 females; median age 54 years; range 22 to 82 years) who underwent surgery and postoperative radiotherapy for oral tongue cancer. Tumor staging based on the AJCC-1997 criteria was as follows: stage I (n=1), stage II (n=21), stage III (n=12), and stage IVA (n=26). Surgery included hemiglossectomy (n=46, 76%), partial (n=13, 22%) and total (n=1, 2%) glossectomy. Neck dissection was performed in 47 patients (78%). Radiotherapy dose was generally 6000 cGy/30 fr. The median follow-up was 51 months (range 5 to 180 months).

RESULTS:

The five-year overall and relapse-free survival rates were 50% and 47%, respectively. Survival at five years was 70% for stage I-III, and 20% for stage IVA. Most of the relapses occurred in the first two years after treatment. Recurrences were encountered in 31 patients (52%). The median survival after recurrence was eight months (range 1 to 53 months). In multivariate analyses, significant prognostic factors for overall survival and locoregional control were tumor size, stage, N stage, extracapsular lymph node spread, and total duration of radiotherapy. Complications were within acceptable limits.

CONCLUSION:

Postoperative radiotherapy should be standard for patients with stage III and IVA tongue cancer.

• Authors: Ahmet Karadeniz, Mert Saynak, Züleyha Kadehci, Merdan Fayda, Görkem Aksu, Hümeyra Kocaelli, Günter Hafiz
• Journal: Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat (Kulak Burun Bogaz Ihtis Derg) Vol. 17 Issue 1 Pg. 1-6 ( 2007) ISSN: 1300-7475 [Print] Turkey
• Vernacular Title: Dil kanserinde kombine tedavi (cerrahi ve radyoterapi) sonuçlari ve prognostik faktörler.
• PMID: 17483603 (Publication Type: Evaluation Study, Journal Article)

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Squamous Cell (mortality, pathology, radiotherapy, surgery)
• Combined Modality Therapy
• Disease-Free Survival
• Female
• Humans
• Male
• Middle Aged
• Neoplasm Recurrence, Local (mortality, pathology, radiotherapy, surgery)
• Neoplasm Staging
• Survival Analysis
• Tongue Neoplasms (mortality, pathology, radiotherapy, surgery)
• Treatment Outcome
• Turkey (epidemiology)