Xp11 translocation carcinoma of the kidney presenting with multilocular cystic renal cell carcinoma-like features.

Abstract

Reported is the case of a 17-year-old girl with a multicystic tumor in the middle of the right kidney. Partial nephrectomy revealed an epithelial neoplasm with multilocular cystic renal cell carcinoma pattern. The cells exhibited strong nuclear reactivity for TFE3 protein and supported the diagnosis of Xp11 translocation carcinoma of the kidney. A similar case has not been found in the literature. The example emphasizes the high index of suspicion needed for an accurate diagnosis of renal carcinomas.

• Authors: Sueli Suzigan, Ricardo Drut, Paulo Faria, Pedram Argani, Angelo M De Marzo, Rui Nogueira Barbosa, Eliseu Roberto Mello Denadai, Júlio Martins-Filho, Rubens Carlos Martucci, Tufik Bauab Jr
• Journal: International journal of surgical pathology (Int J Surg Pathol) Vol. 15 Issue 2 Pg. 199-203 (Apr 2007) ISSN: 1066-8969 [Print] United States
• PMID: 17478783 (Publication Type: Case Reports, Journal Article)

Chemical References

• Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
• TFE3 protein, human

Topics

• Adolescent
• Basic Helix-Loop-Helix Leucine Zipper Transcription Factors (metabolism)
• Carcinoma, Renal Cell (genetics, metabolism, pathology)
• Cell Nucleus (metabolism, pathology)
• Chromosomes, Human, Pair 1
• Chromosomes, Human, X
• Female
• Humans
• Kidney Neoplasms (genetics, metabolism, pathology)
• Nephrectomy
• Translocation, Genetic