Abstract | OBJECTIVES: METHODS: RESULTS: Between May 2003 and November 2005, 24 men with confirmed L2 proctitis and 15 men with non-LGV rectal chlamydial infection were recruited. In multivariable analyses, both high titre of IgA within 14 days after detection of the infection and older age of the individual were found significantly associated with L2 proctitis (p<0.001 and p = 0.001, respectively). A total sum score of seven times IgA titre and individual's age >or=50 years resulted in an overall sensitivity of 92% and specificity of 100%. This total sum score was highly accurate for detection of LGV proctitis, with an area under the curve in a receiver operating characteristic curve of 0.989. CONCLUSIONS: An increased IgA antibody response and the age of the infected individual are of possible diagnostic value for (early) detection of LGV proctitis.
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Authors | Eric M van der Snoek, Jacobus M Ossewaarde, Willem I van der Meijden, Paul G H Mulder, H Bing Thio |
Journal | Sexually transmitted infections
(Sex Transm Infect)
Vol. 83
Issue 4
Pg. 330-4
(Jul 2007)
ISSN: 1368-4973 [Print] England |
PMID | 17475689
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Bacterial
- Immunoglobulin A
- Immunoglobulin M
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Topics |
- Adult
- Antibodies, Bacterial
(blood)
- Bisexuality
- Chlamydia trachomatis
(immunology)
- Diagnosis, Differential
- Genotype
- HIV Seropositivity
(complications)
- Homosexuality, Male
- Humans
- Immunoglobulin A
- Immunoglobulin M
- Lymphogranuloma Venereum
(complications, diagnosis)
- Male
- Multivariate Analysis
- Proctitis
(diagnosis, microbiology)
- ROC Curve
- Rectal Diseases
(diagnosis)
- Sensitivity and Specificity
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