Evaluation of lidocaine treatment and risk factors for death associated with gastric dilatation and volvulus in dogs: 112 cases (1997-2005).

Abstract

OBJECTIVE:

To determine clinical features, outcome, risk factors for death, and efficacy of IV administration of lidocaine as a prophylactic treatment for ischemic reperfusion injury in gastric dilatation and volvulus (GDV) in dogs.

DESIGN:

Retrospective case series.

ANIMALS:

112 dogs with GDV.

PROCEDURES:

Data pertaining to breed; time lag to admission; clinical, clinicopathologic, and surgical findings; lidocaine treatment; and postoperative complications were assessed for association with outcome.

RESULTS:

German Shepherd Dogs (28.6%) and Great Danes (17%) were significantly over-represented. Risk factors for death included time lag (> or = 5 hours vs < 5 hours) from onset of clinical signs to admission (46.0% vs 11.3%), rectal temperature (< or = 38 degrees C vs > 38 degrees C [< 100.4 degrees F vs > 100.4 degrees F]) at admission (40.0% vs 14.9%), presence or absence of ARF (67.0% vs 23.3%), presence or absence of suspected gastric wall necrosis (59.3% vs 16.0%), and untreated gastric wall necrosis, compared with treated gastric wall necrosis (100% vs 47.6%). Overall mortality rate was 26.8%; no significant differences were detected in mortality rate or postoperative complications between dogs that received lidocaine IV prior to surgical intervention (52.0%) and dogs that did not (48.0%). Mean +/- SD hospitalization time was longer in the lidocaine treatment group (3.5 +/- 1.9 days vs 2.5 +/- 1.4 days).

CONCLUSIONS AND CLINICAL RELEVANCE:

Presence of the identified risk factors should warrant aggressive treatment. Lidocaine treatment was not associated with mortality rate or postoperative complications, but was associated with prolonged hospitalization time.

• Authors: Tali Buber, Joseph Saragusty, Eyal Ranen, Ana Epstein, Tali Bdolah-Abram, Yaron Bruchim
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 230 Issue 9 Pg. 1334-9 (May 01 2007) ISSN: 0003-1488 [Print] United States
• PMID: 17472559 (Publication Type: Journal Article)

Chemical References

• Lidocaine

Topics

• Animals
• Breeding
• Dog Diseases (drug therapy, mortality, surgery)
• Dogs
• Female
• Gastric Dilatation (drug therapy, mortality, surgery, veterinary)
• Genetic Predisposition to Disease
• Lidocaine (adverse effects, therapeutic use)
• Male
• Postoperative Complications (epidemiology, veterinary)
• Prognosis
• Prospective Studies
• Reperfusion Injury (prevention & control, veterinary)
• Risk Factors
• Stomach Volvulus (drug therapy, mortality, surgery, veterinary)
• Survival Rate
• Treatment Outcome