[Immunological aspects of postoperative analgesia after abdominal hysterectomy].

Abstract

BACKGROUND:

Prostaglandins modulate cytokine release though increases in cAMP, regulating interleukin-6 and interleukin-10. Ketoprofen inhibits cyclo-oxygenase activity and hence prostaglandin production.

AIM:

We hypothesized that ketoprofen would affect release of IL-6 and IL-10 and modulate the immune response.

METHOD:

We have evaluated 40 women, divided into four groups by the model of postoperative pain treatment: control group (only opioid) and experimental group (combination of i.v. ketoprofen and opioid). Serum IL-6 and IL-10 were measured before surgery, 24 and 72 hours after skin incision. Due to days in hospital we detected temperature and severe complications.

RESULTS:

IL-6 increased at 24h and normalized at 72h. In contrast IL-10 did not change significantly.

CONCLUSION:

The two models of postoperative analgesia have both modulated immune response after abdominal hysterectomy in same way.

• Authors: B Tablov, S Stavreva, V Tablov, I Popov, E Konova
• Journal: Akusherstvo i ginekologiia (Akush Ginekol (Sofiia)) Vol. 46 Issue 1 Pg. 18-24 ( 2007) ISSN: 0324-0959 [Print] Bulgaria
• PMID: 17469457 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Analgesics, Opioid
• Cyclooxygenase Inhibitors
• Inflammation Mediators
• Interleukin-6
• Prostaglandins
• Interleukin-10
• Ketoprofen

Topics

• Abdomen (surgery)
• Adult
• Analgesia (methods)
• Analgesics, Opioid (administration & dosage, therapeutic use)
• Cyclooxygenase Inhibitors (administration & dosage, adverse effects, therapeutic use)
• Drug Therapy, Combination
• Female
• Humans
• Hysterectomy (methods)
• Inflammation Mediators (blood, immunology)
• Interleukin-10 (blood, immunology)
• Interleukin-6 (blood, immunology)
• Ketoprofen (administration & dosage, adverse effects, therapeutic use)
• Pain, Postoperative (drug therapy, immunology)
• Prostaglandins (blood, immunology)