Abstract | INTRODUCTION: STATE OF THE ART:
Pneumonia is the most common infection occurring after transplant and the infection with the highest mortality. Following the classical, myeloablative approach to transplant, two thirds of the pneumonias that occur are of infectious origin. Their causes roughly follow the timing of the immune reconstitution, and may depend on the type of transplant, the match between donor and recipient, and, overall, the occurrence of graft-versus-host disease. Most bacterial pneumonias occur during the initial neutropenic phase. The 2nd and 3rd month post transplant are mainly complicated by viral pneumonia, especially respiratory virus and adenovirus pneumonia in deeply immunosuppressed patients. Preemptive and prophylactic strategies have considerably reduced the incidence of cytomegalovirus pneumonia. Pneumonia due to encapsulated bacteria, such as Haemophilus influenzae and Streptococcus pneumoniae, usually considered to be late infections, may actually be observed from the second month post-transplant. PERSPECTIVES: CONCLUSIONS: Much remains to be done to decrease the incidence of pneumonia in these patients and to understand their mechanisms.
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Authors | C Cordonnier, C Pautas, M Kuentz, B Maitre, S Maury |
Journal | Revue des maladies respiratoires
(Rev Mal Respir)
Vol. 24
Issue 4 Pt 1
Pg. 523-34
(Apr 2007)
ISSN: 0761-8425 [Print] France |
Vernacular Title | Complications pulmonaires précoces des allogreffes de cellules souches hématopoïétiques. |
PMID | 17468708
(Publication Type: English Abstract, Journal Article, Review)
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Topics |
- Humans
- Pneumonia
(diagnosis, etiology, prevention & control)
- Stem Cell Transplantation
(adverse effects)
- Transplantation Conditioning
- Transplantation, Homologous
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