Preparation and antibacterial activity evaluation of rifampicin-loaded poly lactide-co-glycolide nanoparticles.

Abstract

Biodegradable polymers such as poly lactide-co-glycolides (PLGA) have been considered for the preparation of nanoparticles (NPs). In this study, rifampicin (RIF)-loaded PLGA NPs were fabricated by an emulsification/solvent diffusion method. The effect of several variables on the NPs' characteristics were evaluated, including the amount of RIF, amount of the poly vinyl alcohol as surfactant, and internal-phase volume and composition. The RIF encapsulation efficacy and the particle size distribution were optimized by varying these parameters. NPs were spherical with a relatively monodispersed size distribution. The effect of nanoencapsulation of RIF on the antibacterial activity of RIF against gram-positive and gram-negative bacteria was evaluated. It was shown that RIF NPs could considerably improve the RIF antibacterial efficacy.

• Authors: Farnaz Esmaeili, Mahdi Hosseini-Nasr, Mazda Rad-Malekshahi, Nasrin Samadi, Fatemeh Atyabi, Rassoul Dinarvand
• Journal: Nanomedicine : nanotechnology, biology, and medicine (Nanomedicine) Vol. 3 Issue 2 Pg. 161-7 (Jun 2007) ISSN: 1549-9642 [Electronic] United States
• PMID: 17468055 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Coated Materials, Biocompatible
• Drug Carriers
• Polymers
• Polylactic Acid-Polyglycolic Acid Copolymer
• Polyglycolic Acid
• Lactic Acid
• Rifampin

Topics

• Anti-Bacterial Agents (administration & dosage, chemistry)
• Bacteria (cytology, drug effects)
• Cell Survival (drug effects)
• Coated Materials, Biocompatible (chemistry)
• Drug Carriers (chemistry)
• Lactic Acid (chemistry)
• Materials Testing
• Nanoparticles (chemistry, ultrastructure)
• Polyglycolic Acid (chemistry)
• Polylactic Acid-Polyglycolic Acid Copolymer
• Polymers (chemistry)
• Rifampin (administration & dosage, chemistry)