Transderm scopolamine for the control of perioperative nausea.

A randomized prospective study of 201 patients in two institutions was performed to evaluate the efficacy of a transderm scopolamine patch in the control of postoperative nausea. Of 201 patients, 180 successfully completed the protocol. Demographically, the groups were similar in age, sex, and surgical procedures. Adverse effects were noted in both treatment and control groups. Forty-seven per cent of the placebo and 49 per cent of the transderm scopolamine group did not experience postoperative side effects. The most common adverse reactions were urinary retention, dry mouth, agitation, nausea, and vomiting. There was a reduction in the number of vomiting episodes in the transderm scopolamine treatment group from the control group (21% transderm scopolamine vs. 36% placebo). These differences became more significant among the subgroups in surgery, especially after orthopedic procedures. Thirty-five per cent of the transderm scopolamine group experienced nausea compared with 65 per cent from the placebo, 11 per cent of the transderm scopolamine experienced vomiting compared to 26 per cent. Transderm scopolamine was effective in reducing but not eliminating postoperative nausea.
AuthorsB V Stromberg, D H Reines, J Ackerly
JournalThe American surgeon (Am Surg) Vol. 57 Issue 11 Pg. 712-5 (Nov 1991) ISSN: 0003-1348 [Print] UNITED STATES
PMID1746779 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Placebos
  • Scopolamine Hydrobromide
  • Administration, Cutaneous
  • Adult
  • Double-Blind Method
  • Drug Tolerance
  • Female
  • Humans
  • Male
  • Nausea (prevention & control)
  • Placebos
  • Postoperative Complications (prevention & control)
  • Safety
  • Scopolamine Hydrobromide (administration & dosage, therapeutic use)
  • Time Factors
  • Vomiting (prevention & control)

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