Efficacy of 25% diluted fluticasone propionate 0.05% cream as wet-wrap treatment in cutaneous mastocytosis.

Abstract

BACKGROUND:

Mastocytosis is a disorder that can be subdivided into two forms: cutaneous and systemic. Patients with cutaneous mastocytosis only may suffer from cosmetic problems. Topical steroid application has been shown to be effective in cases of limited skin lesions.

METHODS:

A case-controlled pilot study was conducted during a 6-weeks treatment using diluted 25% fluticasone propionate 0.05% cream under wet-wrap occlusion in 5 adults and 6 children. Improvement was measured up to the 24th week after treatment using the SCORMA Index.

RESULTS:

The results of this pilot study showed a partial but clear cosmetic improvement in 9 of the 11 patients. The mean SCORMA Index decreased after treatment from 38 to 26.

CONCLUSION:

25% dilution of fluticasone propionate 0.05% cream under wet-wrap occlusion is an alternative treatment modality for alleviating the symptoms of cutaneous mastocytosis, but the improvement may be moderate and fall short of the patient's expectations.

• Authors: Rogier Heide, Flora B de Waard-van der Spek, Jan C den Hollander, Bhupendra Tank, Arnold P Oranje
• Journal: Dermatology (Basel, Switzerland) (Dermatology) Vol. 214 Issue 4 Pg. 333-5 ( 2007) ISSN: 1421-9832 [Electronic] Switzerland
• PMID: 17460406 (Publication Type: Journal Article)
• Copyright: 2007 S. Karger AG, Basel

Chemical References

• Androstadienes
• Anti-Inflammatory Agents
• Emollients
• Fluticasone

Topics

• Administration, Topical
• Adult
• Androstadienes (administration & dosage)
• Anti-Inflammatory Agents (administration & dosage)
• Case-Control Studies
• Child
• Emollients
• Fluticasone
• Humans
• Mastocytosis, Cutaneous (drug therapy)
• Occlusive Dressings
• Pilot Projects
• Treatment Outcome