Elloxazinones A and B, New Aminophenoxazinones from Streptomyces griseus Acta 2871.

Abstract	Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.
Authors	Ellen Graf, Kathrin Schneider, Graeme Nicholson, Markus Ströbele, Amanda L Jones, Michael Goodfellow, Winfried Beil, Roderich D Süssmuth, Hans-Peter Fiedler
Journal	The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 60 Issue 4 Pg. 277-84 (Apr 2007) ISSN: 0021-8820 [Print] England
PMID	17456980 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antibiotics, Antineoplastic Oxazines elloxazinone A elloxazinone B
Topics	Antibiotics, Antineoplastic (chemistry, isolation & purification, pharmacology) Cell Cycle (drug effects) Cell Line, Tumor Fermentation Humans Magnetic Resonance Spectroscopy Oxazines (chemistry, isolation & purification, pharmacology) Streptomyces griseus (classification, metabolism) Structure-Activity Relationship

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